Lisdiana, - Pengaruh Paparan Rokok Elektrik terhadap kadar GPx dan Catalase pada darah Tikus. Life Science.

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Abstract

Electric cigarettes are cigarettes that are used with battery power, but do not burn tobacco like ordinary cigarette products. Electric cigarettes were initially said to be safe for health because nicotine solutions contained in e- cigarettes only consist of a mixture of water, propylene glycol, flavor enhancing substances, the aroma of tobacco, and other compounds that do not contain tar, tobacco or other toxic substances common in tobacco cigarettes. Electric cigarettes contain free radical compounds that can cause oxidative stress. In conditions of oxidative stress, free radical compounds increase lipid peroxide. In normal enzyme activity, an increase in the concentration of substrate, namely the molecule hydrogen peroxide (H2O2) can increase enzyme activity. But when the active side of all enzymes binds to the substrate, the addition of the substrate cannot increase the speed of the next enzyme reaction, resulting in a decrease in enzyme activity. This study aimed to analyze the levels of GPx and catalase in rat blood exposed to electrocution cigarettes. The study was conducted on 30 male white rats of Wistar strain which were divided into 5 groups, namely K- (negative control), K + (positive control), KP1 (treatment 1), KP2 (treatment 2) and KP3 (treatment 3). The K + group is a positive control group with 3 cigarettes and KP1, KP2, KP3 electric cigarette treatment groups treated with e-cigarettes with a dose of nicotine 3 mg, 6 mg, 9 mg for 30 days. To find out the difference in GPx and catalase levels, each group was analyzed by using one way annova and LSD for parametric test, while for non-parametric tests using the kruskal wallis test and Mann Whitney test. The results of the analysis showed that all between groups K-, K +, KP1, KP2 and KP3 were significantly different, in the KP3 group had the level of Gpx (40.25 ± 2.03e) and catalase (2.46 ± 9.50e) which was the lowest due to exposure electric cigarette with the highest dose of nicotine which is 9 mg.

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