Sri Sumartiningsih, - and Setya Rahayu, - and Eko Handoyo, - and Jung-Charng Lin, - and Chin Leong Lim, - and Michal Starczewski, - and Philip X. Fuchs, - and Chia-Hua Kuo, - (2022) Systemic Lactate Elevation Induced by Tobacco Smoking during Rest and Exercise Is Not Associated with Nicotine. Working Paper. Universitas Negeri Semarang.

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Abstract

Lactate is a metabolite produced during anaerobic glycolysis for ATP resynthesis, which accumulates during hypoxia and muscle contraction. Tobacco smoking significantly increases blood lactate. Here we conducted a counter-balanced crossover study to examine whether this effect is associated with inhaling nicotine or burned carbon particles. Fifteen male smokers (aged 23 to 26 years) were randomized into 3 inhalation conditions: tobacco smoking, nicotine vaping, and nicotine-free vaping, conducted two days apart. An electronic thermal evaporator (e-cigarette) was used for vaping. We have observed an increased blood lactate (+62%, main effect: p < 0.01) and a decreased blood glucose (

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