Nur Dina Amalina, FMIPA Farmasi and Meiny Suzery, - and Bambang Cahyono, - (2020) Cytotoxic Activity of Hyptis pectinata Extracts on MCF-7 Human Breast Cancer Cells. Indonesian Journal of Cancer Chemoprevention, 11 (1). ISSN 2088–0197

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Abstract

Hyptis pectinata (L.) poit, popularly known in the world as “comb bushmint” is a medicinal plant commonly used for the treatment of throat and skin inflammations, bacterial infection, pain and cancer. The objective of this research is to determine the cytotoxic and antiproliferative effect of Hyptis pectinata ethanolic extract (HPE) on breast cancer cells. The effect HPE on cytotoxicity was examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-dphenyl tetrazolium bromide (MTT) assay on michigan cancer foundation (MCF-7) breast cancer cells. This assay also used to determine cell proliferation over 3 days of treatment with HPE concentration between 1.5–100 µg/mL. HPE showed that exhibited cytotoxic effects with IC50 value of 46 µg/mL for 24 h and changes the physiological morphology on MCF-7 cells. Interestingly, the treatment of HPE for 48 and 72 h highly decreases cell viability on MCF-7 with dose and time-dependent manner compared to untreated cells. These results indicate that HPE has antiproliferative activities and maybe the potential to be used in drug design in an attempt to develop new compounds with fewer side effects when compared to conventional chemotherapy.

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