Mahalul Azam, - Antioxidant Properties of Capsule Dosage Form From Mixed Extracts of Garcinia Mangostana Rind and Solanum Lycopersicum Fruit. ACTA Pharmaceutica Sciencia, 59 (1). ISSN 13072080

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Abstract

Several studies showed both Garcinia mangostana L. and Solanum lycopersicum L. have shown important role as natural sources of antioxidant compounds. Hence, capsule supplement from mixed extracts of Garcinia mangostana L. and Solanum lycopersicum L. was prepared. This study aims to investigate the antioxidant proper�ties from the capsules supplement contained with mixed extracts of Garcinia man�gostana rind (GMR) and Solanum lycopersicum fruit (SLF). Antioxidant activity of capsule dosage form was measured using DPPH, ABTS, and FRAP assays. In addi�tion, the total phenolic content and total flavonoid content of the capsules preparation were also evaluated. Total phenolic content was 0.7082 ± 0.1372 mg GAE/capsule and total flavonoid content was 11.7769 ± 3.9504 µg QE/capsule. The strong correla�tion observed between antioxidant capacity by ABTS method and the total phenolic contents (R2 = 0.995, P<0.05) indicated that phenolic compounds in capsule prepara�tion related with its antioxidant activity. Keywords: Antioxidant, DPPH, ABTS, FRAP, Garcinia mangostana, Solanum ly�copersicum

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