Nugrahaningsih, WH (2020) The allele frequency of C825T GNB3 gene in hypotension. Journal of Physics: Conference Series 6th International Conference on Mathematics, Science, and Education (ICMSE 2019). pp. 1-4. ISSN Print ISSN : 1742-6588 e-ISSN:1742-6596

	PDF (Artikel) Download (974kB)
	PDF (Uji Turnitin) Download (1MB)
	PDF (Peer Review) Download (651kB)
	PDF (Perbaikan PAK) Download (832kB)

Abstract

Abstract. Hypotension is signed by the systolic blood pressure less than 90 mmHg and the diastolic less than 60 mmHg. The prevalence of orthostatic hypotension is high, about 10-33%. Genetic polymorphism one of factors influenced the prevalence of blood pressure abnormality. GNB3 gene located at chromosome 12p13 influenced blood pressure by their involved in the second messenger during the transduction pathway. The survey conducted to 54 volunteers (29 normotension and 25 hypotension). The peripheral blood was collected from brachial vein. GNB3 gene were analysis by PCR-RLFP. DNA extraction was processing by GeneJET Genomic DNA Purification Kit. The genotype frequency of CC: CT:TT was 12%:72%:16% in hypotension, while 21%:52%:17% in normotension. The allele frequency of C:T was 48:52% in hypotension and 46,5:53,5% in normotension. The frequency allele of C and T were difference between hypotension and normotension (p=0.005). Concluded that C825T of GNB3 gene associated with hypotension evidence.

Actions (login required)

View Item